High school homecoming celebrations in Mississippi ended in gunfire, with two separate shootings on opposite sides of the US state that left at least six people dead and many more injured.

Four of the dead were killed in downtown Leland, after a high school football homecoming game in the Mississippi Delta region on the state's western edge, a state senator said yesterday.

About 20 people were injured in the gunfire after people gathered in downtown Leland following the game, state Senator Derrick Simmons said.

Of the 20 wounded, four were in critical condition and flown from a hospital in nearby Greenville to a larger medical centre in the state capital city of Jackson, Simmons told The Associated Press.

Simmons said he was being updated on developments by the Washington County Sherif

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