SANTA CLARA, Calif. (AP) — The San Francisco 49ers overcame a rash on injuries to star players to get off to a fast start to the 2025 season.

The season-ending ankle injury to four-time All-Pro linebacker Fred Warner might be too much as evidenced by how San Francisco’s defense collapsed without its leader in a 30-19 loss to Tampa Bay on Sunday.

Warner got hurt on Tampa Bay’s third offensive drive of the game and San Francisco (4-2) did manage to force a punt on that drive and the next before getting overwhelmed.

The Bucs then scored three touchdowns, one field goal and had one missed field goal on their final five drives as a young defense missing Warner and star pass rusher Nick Bosa had no answers.

Tampa Bay averaged 7.2 yards per play after Warner’s injury, which would be the fifth

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