Interstate 110 south remains closed at North 22nd Street due to a jackknifed tractor-trailer, the state Department of Transportation and Development said at about 2 p.m. Tuesday.
As of 3 p.m., traffic cameras showed the highway was still blocked by the truck.
A Baton Rouge Police spokesperson said that the trailer separated from the truck and spilled its contents onto the interstate. The incident happened at about 4:30 a.m. Tuesday, according to DOTD.
Congestion has reached Weller/Mohican Street, DOTD said.
Motorists are being advised to use an alternate route.