Lori Loughlin will always have a hand to hold onto with John Stamos .

"Forty years I’ve known her," her onscreen husband—who played the Uncle Jesse to her Aunt Becky on the '90s sitcom Full House —said on the Oct. 20 episode of the Good Guys podcast . "You can see through people after a few years. This woman’s a saint."

Throughout the decades, Stamos has seen Loughlin go through tough times—including her recent separation from husband Mossimo Giannulli , which comes nearly five years after they each served prison sentences for their connection to the Varsity Blues college admissions scandal .

Loughlin and Giannulli made headlines in 2019 when they were accused of securing fraudulent admissions for their daughters Isabella Rose Giannulli , 27, and Olivia Jade G

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