Penn State’s Big Ten matchup with Ohio State loomed as the biggest regular-season game in the conference at the beginning of the season.

Not anymore.

After starting 3-0, the Nittany Lions lost four consecutive games heading into its second bye week, the last one a 25-24 defeat to Iowa on Saturday at Kinnick Stadium.

Ryan Day’s Buckeyes, the defending national champs, are ranked No. 1 in the country.

Ohio State (7-0, 4-0) is led by a stout defense that has allowed just 41 points and an offense built around dynamic wideout Jeremiah Smith.

Both programs are on a bye week.

Penn State (3-4, 0-4) and the Buckeyes meet Nov. 1 in Columbus. Kickoff is at noon and the game will be televised by FOX.

The opening point spread for the game is out on FanDuel.

Ohio State, a 34-0 winner at Wisc

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