A review of studies on fecal transplants alleviating symptoms of depression has found the treatment works best when the packages of helpful microbes are delivered straight to our gut through our butts, as opposed to an oral route.

This was particularly the case for people who also have irritable bowel syndrome , the meta-analysis determined. However, they also found that the effects diminished by 6 months.

"Fecal microbiota transplantation exerts a sustained and progressively enhanced antidepressant effect," the researchers found , upon reviewing 12 randomized trials, collectively involving 681 people. The studies, published between 2019 and 2024, were conducted primarily in China, with a few studies also taking place in the US, Australia, Canada, and Finland.

Fecal transpla

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