China: A long-term cohort study published in Diabetes Care has shed light on how changes in body mass index (BMI) from childhood to adulthood impact the risk of developing cardiovascular-kidney-metabolic (CKM) syndrome in midlife. Conducted by Yang Wang and colleagues from the Department of Cardiovascular Medicine at the First Affiliated Hospital of Xi’an Jiaotong University, the 36-year study provides important evidence on how early-life weight trends shape long-term health outcomes.

The research, based on the Hanzhong Adolescent Hypertension Study, followed 1,997 participants aged 6 to 18 years at baseline, tracking them into their late 40s (mean age 48.12 years). Participants were categorized into four BMI trajectory groups: persistently normal, incident overweight (normal BMI in

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