SANTA CLARA, Calif. – The long string of injuries that have haunted the San Francisco 49ers all season finally became too much to overcome for at least one week.

The defense missing its top two players couldn’t get off the field, the offense led by backup quarterback Mac Jones and mostly reserve receivers never got going and the 49ers lost 26-15 to the Houston Texans on Sunday.

The Niners fell into a 16-0 hole, didn’t generate a single first down until the final minute of the first half and allowed a Houston offense that had struggled all season to gain 475 yards and convert 9 of 16 third downs.

“There’s not much to sugarcoat there,” coach Kyle Shanahan said. “I was really disappointed with how we looked for all four quarters. First half was unacceptable. Second half didn’t get much

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