Mike's Week 10 college football betting picks against the spread for Tuesday, October 28, Wednesday, October 29, Thursday, October 30, and Friday, October 31, 2025. Free CFB betting predictions, odds analysis, and ATS picks from RotoBaller.

It wasn't as crazy as Week 8, but hey, few are. We still saw some great finishes, some ranked teams losing, and Indiana being Indiana.

We are down to 53 games this week, with nine of them taking place before Saturday. There are no FBS vs. FCS matchups, so it's a nice and proper week!

We've got some good midweek DFS slates this time around to go with the betting. Keep an eye out for those as well!

CFB Betting Picks for Week 10

I will pick every college football game every week. Not a top five. Not a top 10. All of them. Big deal, right? Lots of peop

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