Prosecutors in Melbourne's Easey Street murder case have told a court that DNA found at the crime scene is highly likely to have come from prime suspect Perry Kouroumblis.

Mr Kouroumblis is set to plead not guilty to murdering Suzanne Armstrong and Susan Bartlett in their Collingwood share house between January 10 and January 13 in 1977.

The 66-year-old is also accused of raping Ms Armstrong.

His legal team says he is not the killer and argues the DNA evidence is unreliable and should be excluded.

Mr Kouroumblis is facing a committal hearing before Magistrate Brett Sonnet, who will decide if the case should proceed to a Supreme Court jury trial.

On Wednesday, details about the crime scene found by police were outlined by prosecutor Zubin Menon, who said the victims were stabbed dozens

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