The death of four people in a catastrophic fire is a tragedy that will send ripples through an entire regional community, a state premier says.

Central Queensland is reeling after the fatal early morning house fire, the second deadly blaze to kill multiple people in the state in less than a month.

The bodies were discovered in the burnt remains after emergency services extinguished the fire at Emerald, police said.

The blaze erupted before 7am on Thursday in the regional town about 270km west of Rockhampton.

A crime scene has been declared, with police and fire investigators launching a major investigation, a Queensland Police Service spokeswoman said.

Police have not released details identifying the four people killed as investigations into the cause of the fire get under way.

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