The top NFL Pick'em pool picks for Week 10 of the 2025 NFL season. Kyle's weekly NFL Pick'em pool targets, avoids, and predictions to help win pick'em contests.

Welcome back to our NFL Pick'em Pool Picks for Week 10 of the 2025 NFL season. As the calendar flipped to November, both the top teams in the NFC and AFC lost in Week 9, with the Packers losing 16-13 as 12.5-point favorites at home to the Panthers on a walk-off Ryan Fitzgerald field goal, and the Colts falling flat at Pittsburgh, losing 27-20. And again, Josh Allen and the Bills took down Patrick Mahomes and the Chiefs for the fifth time in the regular season.

With the trade deadline in the rearview mirror and the second half of the season upon us, Week 10 has a handful of pivotal matchups. All four NFC West teams face off

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