Key Takeaways

Transgender women using estradiol don’t have an increased risk of heart attack or stroke

However, transgender men taking testosterone do have an increased risk

The trends reflect differences in heart health risk between cisgender men and women

THURSDAY, Nov. 6, 2025 (HealthDay News) — Transgender women using estradiol for their transition don’t run an increased risk of heart attack or stroke , a new study says.

In fact, their hormone treatment might have a protective effect on the heart and blood vessels compared to cisgender men, researchers reported Nov. 4 in the European Heart Journal .

However, transgender men using testosterone for their transition do have an increased risk of heart attack and stroke compared to cisgender women, the study found.

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