A preliminary investigation has found that those who use tobacco with cannabis show unique changes to their brain chemistry.

The findings could explain why those who use both often have worse addictions and mental health outcomes than those who use only one or the other.

In 2024, for instance, a study found that young people in the US who use tobacco and cannabis more commonly reported mental health problems than those who used cannabis on its own or only smoked tobacco.

The current study is small and preliminary, but researchers were surprised by the results and want to conduct further trials on those who smoke and vape tobacco .

The team compared the brain scans of 8 participants who reported using only cannabis to 5 participants who reported using tobacco cannabis.

The group

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