MIAMI — For decades, federal prosecutors in South Florida earned a chorus of praise for convicting Colombian drug lords, New York mafia bosses, health care fraudsters, and a spectrum of corrupt cops, judges and politicians.

But now, the Miami-based U.S. Attorney’s Office is undergoing a dramatic transformation as it focuses on two pillars of President Donald Trump’s agenda: a crackdown on illegal immigrants and an investigation into his political “enemies” — with the latter signaling an unprecedented, coordinated mission with the Department of Justice in Washington.

U.S. Attorney Jason Reding Quiñones, who was appointed by Trump, has directed the Southern District of Florida office to open the investigation and issue subpoenas in connection with John O. Brennan, the former CIA director d

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