Brain scientists are seeking weight-loss drugs without the nausea : Shots

Millions of Americans have shed pounds with help from drugs like Wegovy and Zepbound.

But people who take these drugs often experience unpleasant side effects.

"They lose weight, which is a positive thing," says Warren Yacawych of the University of Michigan, "but they experience such severe nausea and vomiting that patients stop treatment."

So at this year's Society for Neuroscience meeting in San Diego, Yacawych and other researchers held a session to describe their efforts to understand and solve the side-effect problem.

The weight-loss products are called GLP-1 agonists . They work by mimicking a hormone that reduces appetite and slows digestion.

Yacawych and his colleagues wanted to know if they could tweak these drugs to suppress appetite without making people queasy.

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