Oregon quarterback Dante Moore looks to pass as the Oregon Ducks host the Minnesota Golden Gophers at Autzen Stadium in Eugene, Oregon.

The No. 16 USC Trojans (8-2, 6-1 Big Ten) and No. 5 Oregon Ducks (9-1, 6-1) meet Saturday at Autzen Stadium in Eugene, Oregon. Kickoff is scheduled for 3:30 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NCAA football odds around the USC vs. Oregon odds and make our expert college football picks and predictions for the best bets.

USC leads the all-time series 38-23-2, but Oregon has won the past 3 meetings since Nov. 11, 2023. This is the first-ever meeting between the teams as members of the Big Ten.

The Trojans topped Iowa 26-21 last Saturday, but the Hawkeyes covered as 6.5-point underdogs as the Under (48.5) cashed. QB Jayden Maiava threw for 254 yards, 1 TD and 11 rushing yards, while hooking up with WR Makai Lemon 10 times for 153 yards and a score. RB Bryan Jackson ran for a pair of scores, too.

USC has won 3 in a row since a 34-24 loss at Notre Dame Oct. 18. It is 3-2 against the spread (ATS) in the past 5 games, and the Under is 4-1 in that span.

The Ducks rolled up a 42-13 victory last Saturday in Eugene, covering as 27-point favorites with the Over (45.5) cashing. QB Dante Moore threw for 306 yards and 2 TDs, while RB Noah Whittington had a wild 72 yards rushing with a 40-yard highlight-reel touchdown. The Ducks have won 4 in a row since a 30-20 loss at home to Indiana Oct. 11. The Under has a slight 2-1 edge in the past 3 games, while going 5-3 in the past 8 outings.

The weather has been dicey in Eugene in multiple games this season, but the forecast is favorable Saturday, with just a 10 percent chance of precipitation with partly cloudy conditions, temperatures around 50 degrees and no wind to speak of.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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USC at Oregon odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:44 a.m. ET.

  • Moneyline (ML): USC +310 (bet $100 to win $310) | Oregon -400 (bet $400 to win $100)
  • Against the spread: USC +10.5 (-115) | Oregon -10.5 (-105)
  • Over/Under (O/U): 59.5 (O: -105 | U: -115)

USC at Oregon picks and predictions

Prediction

Oregon 33, USC 24

Moneyline

Oregon (-400) will set you back 4 times your potential return, and that's way too expensive for a standalone play, or as part of a parlay.

While the Ducks are on a roll, and they're very unlikely to lose a second game at home, you still can't risk this much for such a small reward.

AVOID.

Against the spread

USC +10.5 (-115) is worth a look catching double digits. The Trojans have the weapons on offense to at least keep this deficit within single digits.

Oregon did cover as a 27-point favorite last week against Minnesota, but it is just 2-4-1 ATS in the past 7 games as a favorite dating back to Sept. 13. Tread lightly, though, as USC is 1-3 ATS in 4 road games this season, including both outright losses.

Over/Under

UNDER 59.5 (-115) is the lean, but go with a half-unit play at the highest.

The Under has connected in 4 of the past 5 games for USC since Oct. 11, and the total has gone low in 3 of the past 4 games on the road.

For Oregon, the Under has cashed at a 2-1 clip in the past 3 games, while going 5-3 in 8 outings since mid-September. The Under is 3-1 in the past 4 home games for the Ducks, too.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: USC Trojans at Oregon Ducks odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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