Oregon inside linebacker Bryce Boettcher takes the field ahead of the game as the Oregon Ducks host the Minnesota Golden Gophers on Nov. 14, 2025, at Autzen Stadium in Eugene, Oregon.

College Football Playoff implications are on the line in arguably the game of the week with No. 5 Oregon hosting No. 16 Southern California in a West Coast Big Ten battle.

The Ducks have positioned themselves for a return to the playoff, with a signature win being all they're missing. Beat the Trojans and it's nearly a lock for Oregon to be in the field, but a loss could be devastating for Dan Lanning's squad, making it important to defend home territory.

There's plenty of intrigue in USC, as the Trojans remain alive in the hunt for their first playoff appearance. This is the most important game of the season for Lincoln Riley. Win, and USC can jump into the projected field. Lose, and it's another disappointing end in Los Angeles.

Stream Oregon vs. USC football live on Fubo (free trial)

Which team will see its odds boosted and the other shattered? Here's how to watch the Oregon-USC game, including time, TV channel and streaming information, and game odds:

What TV channel is USC vs Oregon on today?

  • TV: CBS
  • Streaming: Fubo (free trial)

Oregon vs. USC will air nationally on CBS in Week 13 of the 2025 college football season from Autzen Stadium in Eugene, Oregon. Brad Nessler (play-by-play) and Gary Danielson (analyst) will call the game from the booth while Jenny Dell will serve as the sideline reporter.

Streaming options include Fubo, which offers a free trial to potential subscribers.

USC vs Oregon time today?

  • Date: Saturday, Nov. 22
  • Time: 3:30 p.m. ET, 12:30 p.m. PT

The Week 13 matchup between Oregon and USC is scheduled to start at 3:30 p.m. ET (12:30 p.m. local time) on Saturday, Nov. 22.

USC vs Oregon predictions, picks, odds

Odds courtesy of BetMGM as of Thursday, Nov. 20:

  • Spread: Oregon (-9.5)
  • Over/under: 59.5
  • Moneyline: Oregon (-375); USC (+300)

Prediction: Oregon 34, USC 27

Both offenses will have a chance to shine, but the Trojans aren't able to slow down Oregon. The Ducks defense tightens up and forces USC to make mistakes at the end to punctuate a much-needed victory.

This article originally appeared on USA TODAY: Where to watch USC vs Oregon today: Time, TV channel, prediction, odds

Reporting by Jordan Mendoza, USA TODAY / USA TODAY

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