Week 12 of the NFL season wraps up with a pair of playoff hopefuls facing off when the Carolina Panthers visit the San Francisco 49ers on "Monday Night Football."

Bryce Young is coming off the best game of his career, passing for 448 yards and three TDs in an overtime win over the Atlanta Falcons that moved the Panthers to 6-5, good for second place in the NFC South.

Despite allowing 452 passing yards to the Arizona Cardinals last week, the 49ers had no trouble cruising to a 41-22 win in Brock Purdy 's return to the lineup. The win moved the 49ers to 7-4 in the tightly packed NFC West.

San Francisco is a touchdown favorite over Carolina in the teams' first meeting since 2022.

Matt Bowen, Liz Loza and Pamela Maldonado offer their picks, prop plays and analysis to help you

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