How many Hulks could a Hulkbuster bust if a Hulkbuster could bust Hulks? Canonically, zero.
Outside his main line of armor, no special suit in Iron Man's repertoire is more iconic than the Hulkbuster. This is why it's ironic that despite all of Tony Stark's bravado and the armor's ambitious naming scheme, the armor specifically designed to put down Hulks has consistently failed to put up results.
Tony Stark's Hulkbuster Armor Is Hilariously Mislabeled
Iron Man reveals his Celestial Hulkbuster Armor in Thor comics
First debuting in 1994's Iron Man #304, the Hulkbuster armor is a bulky set of armor specifically designed to withstand the impact of Hulk's attacks.
In the armor's first fight, Iron Man #305, Tony is faced with Professor Hulk. As a result, the fight ultimately fizzle

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