Teams looking to stay in the mix in their respective divisions clash when the Carolina Panthers battle the San Francisco 49ers on 'Monday Night Football.' Carolina is coming off a 30-27 overtime win over the Atlanta Falcons, while San Francisco rolled to a 41-22 win over the Arizona Cardinals in Week 11. The Panthers (6-5), who are second in the NFC South, are 3-3 on the road this season. The 49ers (7-4), who are third in the NFC West, are 2-2 on their home field in 2025.

Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8:15 p.m. ET. San Francisco is a 7-point favorite in the latest Panthers vs. 49ers odds, while the over/under for total points scored is 49.5. Before locking in any 49ers vs. Panthers picks, make sure you check out what SportsLine NFL expert Micah Rober

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