Western Michigan sophomore Broc Lowry scores a touchdown during the home-opening game against North Texas at Western Michigan University on Saturday, Sept. 6, 2025.

Rivalry week and the final week of the regular season are big all across the country, and the MAC starts that off this week with a Tuesday night matchup featuring a team looking to punch a ticket ot the conference title.

The Western Michigan Broncos (7-4, 6-1 MAC) will head to Ypsilanti, Michigan, to take on the Eastern Michigan Eagles (4-7, 3-4 MAC) from Rynearson Stadium with a MAC Championship Game spot on the line.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Western Michigan vs. Eastern Michigan game odds:

All college football odds via BetMGM

  • Spread: Western Michigan -6.5 (-115), Eastern Michigan +6.5 (-105)
  • Money Line: Western Michigan -275, Eastern Michigan +210
  • Over-Under: Over 46.5 (-115), Under 46.5 (-105)

Western Michigan vs. Eastern Michigan prediction, pick:

Will Eastern Michigan be able to find enough offense in this one to pull off the upset and potentially ruin Western Michigan's season?

Western Michigan doesn't score a ton, just 23 points per game, but what they do incredibly well is play defense. They are No. 18 in scoring defense, and allow only 162 passing yards per game, 126 rushing yards per game, and 3.6 rushing yards per carry.

The problem that the Eagles have is the run defense. They give up 228 yards per game and 5.5 yards per carry. Western Michigan runs the ball 64% of the time and does it well with QB Broc Lowry (783 yards) and RB Jalen Buckley (566 yards).

The Broncos trust the ground game and punch a ticket to the MAC Conference Championship game.

Prediction: Western Michigan 24, Eastern Michigan 10

Best Bet: Western Michigan -6.5

Western Michigan vs. Eastern Michigan channel, start time, streaming:

Time: 7:30 p.m. ET

TV Channel: ESPN2

Live Stream: ESPN App

Watch Western Michigan vs. Eastern Michigan on FuboTV (free trial)

Get more betting analysis and predictions at Sportsbook Wire.

Contact/Follow @College_Wire on X and @College_Wires on Threads. Like our page on Facebook to follow ongoing coverage of college sports news, notes, and opinions.

This article originally appeared on College Sports Wire: Western Michigan vs. Eastern Michigan: College Football Betting Odds

Reporting by Riley Donald, College Sports Wire / College Sports Wire

USA TODAY Network via Reuters Connect