Week 13 of the 2025 NFL season is an eventful one with three games on Thursday due to Thanksgiving Day, a Friday game, the usual Sunday slate and of course, Monday Night Football. All 32 teams will be in action this week, which means there's no shortage of NFL betting opportunities. But that also means there's plenty of NFL line movement to keep track of. Here, we break down the games that have seen the biggest shifts since lines first opened, with all odds courtesy of DraftKings Sportsbook, where new users get $200 in bonus bets and three months of NBA League Pass if your first bet wins :

49ers vs. Browns (1 p.m. ET)

Open : 49ers -6, O/U 40.5

Now: 49ers -5.5, O/U 35.5

The 49ers won on Monday, but their 20-point performance against an average Carolina defense hardly inspi

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