Cleveland Cavaliers guard Donovan Mitchell (45) at Gainbridge Fieldhouse in Indianapolis, Indiana.

The Portland Trail Blazers (8-13) and Cleveland Cavaliers (13-9) meet Wednesday at Rocket Arena in Cleveland, Ohio. Tip-off is scheduled for 7 p.m. ET. Let's analyze BetMGM Sportsbook's NBA odds around the Trail Blazers vs. Cavaliers odds and make our expert NBA picks and predictions for the best bets.

2024-25 season series: Cavaliers swept 2-0

Cleveland swept the season series in 2024-25, but it only won 133-129 in overtime at home on March 2, while Portland easily covered as 10.5-point underdogs as the Over (236.5) cashed in a game that featured 53 foul calls. The Blazers were actually up 18 in that game, before the Cavs rallied without G Donovan Mitchell, who was resting.

Blazers G Deni Avdija had 30 points, 12 rebounds and 10 assists for his first career triple-double in last season's OT loss in Cleveland. The 24-year-old has had 2 more triple-doubles this season, including 31 points, a career-high 19 rebounds and 10 assists in a loss to Oklahoma City on Nov. 30.

Portland lost 121-118 in Toronto Tuesday, covering as 5-point underdogs as the Over (231.5) cashed. The Blazers are 2-1 SU and 3-0 against the spread (ATS) when playing on no rest this season, but the Under is 2-1 in those outings.

The Cavaliers pounded the Indiana Pacers 135-119 in Indianapolis on Monday night as 5-point favorites, halting an 0-3 ATS skid. Mitchell went bonkers, going for 43 points, 9 boards, 7 assists and 4 triples, while shooting 16-of-27 from the field. The Over was a rarity, too, as the Under is still 7-2 across the past 9 games since Nov. 15.

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Trail Blazers at Cavaliers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:24 a.m. ET.

  • Moneyline (ML): Trail Blazers +360 (bet $100 to win $360) | Cavaliers -475 (bet $475 to win $100)
  • Against the spread: Trail Blazers +10.5 (-118) | Cavaliers -10.5 (-102)
  • Over/Under (O/U): 240.5 (O: -110 | U: -110)

Trail Blazers at Cavaliers injuries

Trail Blazers

(Not yet submitted -- below was for Tuesday's game)

  • G Scoot Henderson (hamstring) out
  • G Jrue Holiday (calf) out
  • G Damian Lillard (Achilles) out for season

Cavaliers

  • C Jarrett Allen (finger) out
  • G Lonzo Ball (illness) probable
  • G Sam Merrill (hand) out
  • F Larry Nance Jr. (calf) out
  • F Max Strus (foot) out

For most recent updates: Official NBA injury report.

Trail Blazers at Cavaliers picks and predictions

Prediction

Cavaliers 121, Trail Blazers 114

Moneyline

PASS.

The Cavaliers (-475) will cost you nearly 5 times your potential return, and that's way too much risk for not nearly enough reward. Even if you were to toss Cleveland into a multi-leg parlay, it's way too expensive, decreasing the value of your bet slip.

Look to the spread instead.

Against the spread

The TRAIL BLAZERS +10.5 (-118) have dug down deep and found a way to at least be competitive this season when playing on no rest. In fact, they've covered all 3 instances when playing the second end of a back-to-back. In fact, Portland is an impressive 13-0 ATS in the past 13 times playing on no rest. The last time it failed to cover on no rest was Nov. 8, 2024 in Minnesota.

The Cavaliers are just 1-3 ATS in the past 4 games, and 2-5 ATS across the previous 7 outings, while going 4-9 ATS in the past 13 contests.

Over/Under

The UNDER 240.5 (-110) is worth a look, but don't get carried away.

While the Over has cashed in 2 of the past 3 games for Cleveland, the Under is 7-2 in the past 9 outings. For Portland, it has hit high in 2 in a row, but the Under has a slight 4-3 edge in the past 7 games.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: Portland Trail Blazers at Cleveland Cavaliers odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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