Germany: A study published in JAMA has revealed that in high-risk patients undergoing major abdominal surgery , tailoring perioperative cto preoperative nighttime mean arterial pressure (MAP) did not reduce rates of acute kidney injury , myocardial injury, nonfatal cardiac arrest, or death within 7 days compared with standard management using a MAP target of ≥65 mm Hg. The trial—known as the IMPROVE-multi randomized clinical trial—was led by Bernd Saugel and colleagues from the Department of Anesthesiology at the University Medical Center Hamburg-Eppendorf, Germany. The researchers aimed to determine whether customizing blood pressure goals based on a patient’s preoperative nighttime MAP could better prevent organ injury, which is often linked to intraoperative hypotension. The

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