The on-again, off-again relationship between wide receiver Brandon Aiyuk and the San Francisco 49ers looks to be off again. Potentially for good this time.

The 49ers placed the wide receiver on the reserve/left squad list, making him ineligible to return to the field this season. That not only ends his 2025 season, but it may have ended his career with the 49ers.

Brandon Aiyuk's time with 49ers seems to be over

The 49ers had already voided the guaranteed money in Aiyuk's contract in 2026, setting the stage for a potential parting of ways this offseason. That led to reports of him not participating in meetings or being around the team, and questions as to whether or not he would play again this season.

Now we know for sure he is not.

It continues what has been a messy relationship

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