Psoriasiform Dermatitis Risk in Children on TNFi Reviewed

TOPLINE:

Older age at TNF alpha inhibitors initiation, a diagnosis of juvenile idiopathic arthritis (JIA), and concomitant immunomodulator use were associated with delayed onset of paradoxical psoriasiform dermatitis (PD) in children treated with TNFi, in a retrospective chart review.

METHODOLOGY:

Researchers conducted a retrospective chart review of 3418 patients receiving TNFi therapy for various conditions (including Crohn’s disease, JIA, and ulcerative colitis) at Cincinnati Children’s Hospital Medical Center, Cincinnati, from January 2018 to January 2023.

Overall, 70 patients (2%) developed PD skin eruptions (52.9% women; 91.4% White; 5.7% Black; median age at TNFi initiation, 11.7 years; median age at PD onset, 13.6 years); 21.4% of patients were given concomitant immunomodulator