TOPLINE:

Among older adults living with HIV, more than half experienced polypharmacy, with 49.3% taking potentially inappropriate medications (PIMs) and 55.7% having a high sedative burden. These medication-related factors were associated with nearly twofold increased risks for falls and frailty.

METHODOLOGY:

Researchers conducted a cross-sectional analysis of an ongoing prospective cohort (CHANGE-HIV) to determine the prevalence of polypharmacy and its association with frailty and falls among older adults with HIV infection.

They included 440 patients (median age, 69 years; 91.6% men; median time since HIV diagnosis, 26 years) from seven centers in Canada.

Polypharmacy (prescription of 5 or more nonantiretroviral drugs), severe polypharmacy (prescription of 10 or more nonantiretrovir

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