Benadryl (diphenhydramine), an antihistamine used to relieve allergy and cold symptoms, can cause some serious side effects, especially when taken incorrectly.

A new review published in the World Allergy Organization Journal urges a reevaluation of the drug’s safety, arguing its risks now outweigh its benefits.

Documented Side Effects of Benadryl

According to the review, diphenhydramine (the active ingredient in Benadryl ) was approved by the Food and Drug Administration (FDA) in 1946, well before today’s more rigorous drug testing standards.

Since then, severe side effects—including sedation and impaired concentration—have become well documented. Meanwhile, newer antihistamines with safer profiles , like Allegra (fexofenadine), are now widely available.

"The authors correct

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