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The virus, spread by insects or direct contact, poses no threat to humans.
While usually not harmful to wild rabbits, the virus can be more serious for domestic rabbits.
Cottontail rabbits with horn-like growths on their heads have appeared in Fort Collins in recent weeks, causing concern of the health risk to the rabbits and humans.
Colorado Parks and Wildlife spokesperson Kara Van Hoose said she was notified by the public late last week of rabbits with effects of the rabbit papillomas, a skin virus that produces horn-like growths or black nodules mostly around the head.
Van Hoose said despite the appearance, the growths have no significant effects on wild rabbits unless they impact the rabbit's eyes or mouths and interfere with seeing and eating or drinking.
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