Factors differ by pulmonary hypertension in COPD phenotype

Key takeaways:

This analysis examined three phenotypes of pulmonary hypertension (PH) associated with COPD.

Patients with end-stage COPD with or without PH had the highest median total emphysema index.

Perspective from Shameek Gayen, MD

Patients with end-stage COPD with or without pulmonary hypertension had significantly different clinical, hemodynamic and imaging characteristics from patients with mild COPD with a pulmonary vascular phenotype, according to study results.

The analysis that revealed this finding was published in ERJ Open Research .

Data were derived from Steger M, et al. ERJ Open Res . 2025;doi:10.1183/23120541.00716-2024.

“Our results support the complexity of PH-COPD , with phenotypes ranging from PH associated with end-stage disease (phenotype 1), characte