Primary aldosteronism guideline calls for expanded screening

Key takeaways:

An updated clinical practice guideline recommended screening all people with hypertension for primary aldosteronism.

Mineralocorticoid receptor antagonists should be prescribed as first-line medical therapy.

SAN FRANCISCO — A new clinical practice guideline for primary aldosteronism emphasized screening all patients with hypertension.

The Endocrine Society published its first update to the primary aldosteronism clinical practice guideline since 2016 in T he Journal of Clinical Endocrinology & Metabolism . The guideline, which was also discussed during a symposium at ENDO 2025, focused heavily on expanding screening for primary aldosteronism and discussing treatment options with patients, especially those who may be candidates for surgery.

Gail K. Adler, MD, PhD, FAH