Esophageal cancer makes up about 1% of all cancer cases in the U.S., and it affects over 600,000 people globally each year. According to the American Cancer Society, about 22,000 new esophageal cancer cases were diagnosed in 2025 in the U.S., and over 16,000 deaths were attributed to the disease. Risk factors for this carcinoma include obesity, gastroesophageal reflux disease (GERD) and Barrett’s esophagus.
Barrett’s esophagus is a condition in which the normally flat epithelial cells of the esophagus gradually change to resemble columnar cells in the intestinal tract. The condition is the only known precursor of esophageal cancer, and it is estimated to affect over 300 million people worldwide. The exact cause of Barrett’s esophagus is not known, but chronic esophageal mucosal damage cau