Key points

In 2023, there were 49,316 suicides in the U.S., about 1 death every 11 minutes.

Many attempted-suicide survivors say they regretted their act.

Ketamine may be the first treatment for reversing suicidal thinking in depression.

According to the Centers for Disease Control and Prevention, nearly 13 million individuals seriously consider suicide annually, and around 1.5 million attempt suicide. Preliminary data for 2024 indicate a potential increase in the age-adjusted suicide rate, estimated at 14.7 per 100,000 people. In the nearly two years since the launch of the 988 Suicide and Crisis Lifeline in 2022, the phone line has received more than 10 million contacts. Monthly call volume has surpassed 600,000 calls per month since early 2025.

On August 11, 2025, the U.S. Food and

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