The San Francisco 49ers made the expected move to have wide receiver Brandon Aiyuk miss multiple weeks to start the season as the team announced final moves to reach a 53-man roster by Tuesday's 1 p.m. PT deadline.

Aiyuk and safety Malik Mustapha were placed on the reserve physically-unable-to-perform list, which means they will be inactive for at least the first four games of the season before they will be allowed to practice with the team.

Head coach Kyle Shanahan said earlier this month that the team was eyeing Week 6 as a possible return date for Aiyuk, who tore his MCL and ACL in October of last season in Week 7. Mustapha had surgery to repair an ACL injury earlier this year and is believed to be on a similar return timeline.

Notable 49ers roster cuts

Among the final day roster cu

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