College football is back with Week 1 of the 2025 season. Time to make some predictions.

Each week, I’ll be sharing college football picks against the spread. We’ll cover the biggest games of the weekend while sprinkling in under-the-radar matchups, too. We’ll keep track throughout the season and see how we’re doing.

Let’s get right to it.

(All lines as of Tuesday afternoon, courtesy of FanDuel Sportsbook .)

PRIMETIME PICKS

No. 1 Texas at No. 3 Ohio State (-2.5)

Saturday, noon, FOX

This is a CFP semifinal rematch, but both teams look very different now. Ohio State and Texas had 14 and 12 players drafted, respectively. The deciding factor in this one for me isn’t Arch Manning, rather the defensive players returning for Texas. Colin Simmons, Anthony Hill Jr. and Co. should make l

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