Is Joe Mixon out for the season? When is Joe Mixon coming back? The latest Joe Mixon injury update and fantasy football outlook heading into Week 2 of 2025.

Houston Texans running back Joe Mixon spent the entire 204 season working as the primary workhorse in the Houston backfield. Mixon enjoyed a productive campaign but has been dealing with injuries to begin 2025.

Shortly before the regular season, the Texans placed Mixon on the NFI-reserve list due to a foot injury, which will keep him sidelined for at least the first four games. However, the team has not provided many updates since shifting him to the reserve list.

Will Mixon play again this season? Should fantasy managers stash him on their bench? Let's dive in! Be sure to check all of our fantasy football rankings for 2025:

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