The New Orleans Saints host the San Francisco 49ers in a Week 2 NFL showdown. The Niners are coming off of an injury-riddled 2024 season where they finished at the bottom of the NFC West with a 6-11 record, but they are already in the win column in 2025 thanks to a gritty 17-13 win against the Seahawks in Seattle. The Saints went 5-12 in 2024 after dealing with their own injury woes, and they're off to a rough start to this season after falling to the Arizona Cardinals , 20-13. 49ers quarterback Brock Purdy (toe) has been ruled out.

Kickoff from Caesars Superdome is set for 1 p.m. ET. San Francisco is a 3-point favorite in the latest 49ers vs. Saints odds from SportsLine consensus, while the over/under for total points scored is 40.5. The 49ers are -161 money line favorites (risk

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