Aspirin after desensitization ‘may not be effective’

Key takeaways:

Only four of 16 patients who received aspirin treatment after desensitization were deemed “responders.”

A higher proportion of patients receiving aspirin vs. placebo had an adverse event.

Perspective from Renee Matthews, MD

Among adults with chronic rhinosinusitis with nasal polyps, asthma and NSAID-exacerbated respiratory disease, aspirin after desensitization does not benefit most patients vs. placebo, according to data published in Allergy .

“Clinicians should be aware that the treatment of [ NSAID exacerbated respiratory disease (N-ERD)] is shifting more toward biologics, as aspirin treatment after desensitization [ATAD] may not be effective for most patients, despite its low cost,” Alma Helevä , medical student and doctoral researcher at the Universit