Connor Colby, in the lineup for the San Francisco 49ers, will give the offensive line cohesion. He’s in for a challenge against an athletic Arizona Cardinals defensive line. The same is true for the rest of the offensive line.

Kendrick Bourne starts for the injured Jauan Jennings at wide receiver. That means we’re likely to see a bigger dosage of Ricky Pearsall and Christian McCaffrey in the passing game. Kyle Shanahan has done a fantastic job so far creating mismatches with McCaffrey and Pearsall.

On the other side of the ball, Robert Saleh will look to make Kyler Murray dink and dunk his way down the field. Murray has been ultra-conservative through two weeks, having only attempted a pass beyond 20 yards three times. James Conner has yet to get it going on the ground.

If the Cardinals

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