Perth grandmother Donna Nelson will remain in a Japanese prison after losing her appeal to overturn a six-year drug trafficking sentence.

Last year a Japanese court found the 59-year-old guilty of smuggling almost two kilograms of methamphetamine hidden inside a suitcase.

Nelson has maintained her innocence and insisted she was the victim of an online romance scam.

Nelson has been told she has 14 days to launch an appeal to the Supreme Court.

The judges in the Tokyo High Court took about 40 minutes today to hand down their decision, which upheld the original judgement.

They argued none of the defence arguments were valid as Nelson had raised complaints to her online lover in the past and it could not be said that she blindly trusted him.

They said the 59-year-old decided to

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