Key Takeaways

Alcohol and Benadryl both depress the central nervous system (CNS), and combining them can dramatically worsen side effects like drowsiness, slowed breathing, confusion, and impaired coordination.

Even small amounts of alcohol can amplify Benadryl’s sedative effects and interfere with daily functioning.

The risk is higher for older adults, pregnant or breastfeeding individuals, children, and anyone taking other CNS-depressant medications or products.

Benadryl (diphenhydramine) is an over-the-counter (OTC) first-generation antihistamine that treats allergy symptoms but often causes drowsiness and slowed breathing. Combining it with alcohol, another central nervous system depressant, can intensify these effects and lead to life-threatening outcomes.

How Alcohol Intensifi

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