High-performance enzyme engineering company Watchmaker Genomics recently launched TAPS+, a novel technology that allows for simultaneous detection of methylation and genetic variants using a single sample. The chemistry enables simultaneous detection of methylation (5mC), single-nucleotide variants (SNVs), insertions and deletions (indels), and copy number variations (CNVs) from the same DNA molecule. This multimodal approach has broad applications in oncology ranging from early disease detection to therapy response and minimal residual disease detection.

Current methylation analysis typically leverage bisulfite, which converts unmethylated cytosines to thymines, reducing the four-base sequence (ATCG) to three bases. But this method is indiscriminate and damages virtually all DNA in the s

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