Researchers at the Sanford Burnham Prebys Medical Discovery Institute have found variations in how pancreatic ductal adenocarcinoma (PDAC) grows based on the age of the patients and the role played by cancer-associated fibroblasts (CAFs) in altering the tumor microenvironment (TME) that accelerates tumor growth and metastasis in older patients. The findings, published in Cancer Research , show the potential to target age-related changes in the tumor stroma that could make pancreatic cancer therapies more effective for older patients, who represent the majority of those diagnosed with the disease.

“Too often, frailty prevents patients from being able to withstand conventional chemotherapies as well as surgery, and often there aren’t other viable options,” said Cosimo Commisso, PhD, d

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