The 2025 NBA Cup quarterfinals continue on Wednesday as the Los Angeles Lakers (17-6) host the San Antonio Spurs (16-7). The Lakers are the second seed in the West and the Spurs are No. 3. The winner advances to place the winner of Thunder vs. Suns in the semifinals on Saturday. The Spurs will still be without Victor Wembanyama (calf). The Lakers won the first and only other matchup between these teams this season, beating San Antonio 118-116 on Nov. 8.

Tipoff from Crypto.com Arena in Los Angeles is set for 10 p.m. ET. Los Angeles is the 7.5-point favorite in the latest Spurs vs. Lakers odds, while the over/under for total points scored is 241.5. Before making any Lakers vs. Spurs picks, check out the NBA predictions and betting advice from the SportsLine Projection Model .

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