The 49ers will play a key NFC West game on Thursday night without their starting quarterback and both starting wide receivers.

The 49ers on Wednesday ruled out quarterback Brock Purdy with a toe injury. Wide receivers Ricky Pearsall (knee) and Jauan Jennings (ankle, ribs) officially are out for the game, as well.

Pearsall has 20 catches for 327 yards on the season, while Jennings has nine receptions for 129 yards and one touchdown in three games. Jennings was inactive for the 49ers’ Week 3 game against Arizona with an ankle injury.

Backup quarterback Mac Jones will get his third start of the season in place of Purdy.

The 49ers are likely to turn to Kendrick Bourne and Demarcus Robinson to be their top receivers against the Rams.

On Tuesday, Purdy foreshadowed the likelihood t

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