The Oregon football team has rolled through most of its games this season and will look for its first ranked win at Autzen Stadium this season against USC Saturday, Nov. 22.

The Ducks (9-1, 6-1 Big Ten) will also be looking for their fourth straight win over the Trojans (8-2, 6-1). They last played USC at Autzen Stadium in 2023.

Here's what national pundits and oddsmakers say about the Ducks ' chances against the Trojans. Stream Oregon vs. USC

Oregon vs. USC odds, money line, over/under

Odds courtesy of BetMGM as of Thursday, Nov. 20 .

Moneyline: Oregon -380, USC +300

Spread: Oregon by 9.5

Over/under: 59 1/2

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